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  1. The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug d...

    Authors: Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam and Kenneth A. Howard
    Citation: Molecular and Cellular Therapies 2016 4:3
    Content type: Review Published on:

    A Erratum has been published.

  3. Psoriasis is an inflammatory disease characterized by leukocyte skin infiltration. Interestingly, recent works suggest that the migration of dendritic cells (DCs) is abnormal in psoriatic skin. DCs have signif...

    Authors: Rikke Bech, Babak Jalilian, Ralf Agger, Lars Iversen, Mogens Erlandsen, Kristian Otkjaer, Claus Johansen, Søren R. Paludan, Carina A. Rosenberg, Knud Kragballe and Thomas Vorup-Jensen
    Citation: Molecular and Cellular Therapies 2016 4:1
    Content type: Research article Published on:

  4. Medulloblastoma (MB) is the most common malignant childhood brain tumor with the propensity to disseminate at an early stage, and is associated with high morbidity. New treatment strategies are needed to impro...

    Authors: Brigitte Bisaro, Giorgia Mandili, Alice Poli, Andrea Piolatto, Valentina Papa, Francesco Novelli, Giovanna Cenacchi, Marco Forni and Cristina Zanini
    Citation: Molecular and Cellular Therapies 2015 3:8
    Content type: Research article Published on:

  5. Soluble TNF superfamily (TNFSF) ligands are less stable and less active than their transmembrane (tm) analogues. This is a problem for the therapeutic use of recombinant TNFSF ligands in diverse diseases inclu...

    Authors: Liqin Ban, Willem Kuhtreiber, John Butterworth, Yoshiaki Okubo, Éva S. Vanamee and Denise L. Faustman
    Citation: Molecular and Cellular Therapies 2015 3:7
    Content type: Short report Published on:

  6. Hemorrhoids are a common disorder that affects the quality of life of millions of people worldwide. The effectiveness of OTC medication is limited and they mainly provide symptomatic relief. In order to treat ...

    Authors: Ehud Klein, Ron Shapiro, Jose Ben-Dahan, Moshe Simcha, Yosef Azuri and Ada Rosen
    Citation: Molecular and Cellular Therapies 2015 3:6
    Content type: Research article Published on:

  7. Long noncoding RNAs are emerging as key players in various fundamental biological processes. We highlight the varied molecular mechanisms by which lncRNAs modulate gene expression in diverse cellular contexts ...

    Authors: Roshan Fatima, Vijay Suresh Akhade, Debosree Pal and Satyanarayana MR Rao
    Citation: Molecular and Cellular Therapies 2015 3:5
    Content type: Review Published on:

  8. Toll-like receptor family (TLRs), pattern recognition receptors, is expressed not only on immune cells but also on non-immune cells, including cardiomyocytes, fibroblasts, and vascular endothelial cells. One m...

    Authors: Fatemeh Pourrajab, Mohammad Baghi Yazdi, Mojtaba Babaei Zarch, Mohammadali Babaei Zarch and Seyedhossein Hekmatimoghaddam
    Citation: Molecular and Cellular Therapies 2015 3:4
    Content type: Review Published on:

  9. Desferrioxamine (DFO), deferiprone (L1) and desferasirox (ICL-670) are clinically approved iron chelators used to treat secondary iron overload. Although iron chelators have been utilized since the 1960s and t...

    Authors: Jasmine L Hamilton and Jayachandran N Kizhakkedathu
    Citation: Molecular and Cellular Therapies 2015 3:3
    Content type: Review Published on:

  10. Technological advances allowing high throughput analyses across numerous cancer tissues have allowed much progress in understanding complex cellular signaling. In the future, the genetic landscape in cancer ma...

    Authors: Lars Fransecky, Liliana H Mochmann and Claudia D Baldus
    Citation: Molecular and Cellular Therapies 2015 3:2
    Content type: Review Published on:

  11. The canonical Wnt signaling pathway is involved in a variety of biological processes like cell proliferation, cell polarity, and cell fate determination. This pathway has been extensively investigated as its d...

    Authors: Maria Vittoria Enzo, Marco Rastrelli, Carlo Riccardo Rossi, Uros Hladnik and Daniela Segat
    Citation: Molecular and Cellular Therapies 2015 3:1
    Content type: Review Published on:

  12. A renewed understanding of Trauma Induced Coagulopathy (TIC) has implicated platelets as a crucial mediator and potential therapeutic target in hemostasis. While the importance of abnormal coagulation tests is...

    Authors: Noelle N Saillant and Carrie A Sims
    Citation: Molecular and Cellular Therapies 2014 2:37
    Content type: Review Published on:

  13. Endometriosis is a chronic, estrogen-dependent disease associated with infertility and pelvic pain. Endometriosis is defined by the presence of extra-uterine endometrial tissue. It affects approximately 10% of...

    Authors: Sachiko Matsuzaki, Revaz Botchorishvili, Jean Luc Pouly and Michel Canis
    Citation: Molecular and Cellular Therapies 2014 2:36
    Content type: Review Published on:

  14. In fields such as cancer biology and regenerative medicine, obtaining information regarding cell bio-distribution, tropism, status, and other cellular functions are highly desired. Understanding cancer behavio...

    Authors: Christian Wiraja, David Yeo, Daniel Lio, Louai Labanieh, Mengrou Lu, Weian Zhao and Chenjie Xu
    Citation: Molecular and Cellular Therapies 2014 2:33
    Content type: Review Published on:

  15. Members of the PI3K/Akt/mTor signaling cascade are among the most frequently altered proteins in cancer, yet the therapeutic application of pharmacological inhibitors of this signaling network, either as monot...

    Authors: Mike-Andrew Westhoff, Georg Karpel-Massler, Oliver Brühl, Stefanie Enzenmüller, Katia La Ferla-Brühl, Markus D Siegelin, Lisa Nonnenmacher and Klaus-Michael Debatin
    Citation: Molecular and Cellular Therapies 2014 2:32
    Content type: Review Published on:

  16. Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological functi...

    Authors: Simona Casarosa, Yuri Bozzi and Luciano Conti
    Citation: Molecular and Cellular Therapies 2014 2:31
    Content type: Review Published on:

  17. MicroRNAs (miRNAs) are small noncoding RNAs that can function as either powerful tumor promoters or suppressors in numerous types of cancer. The ability of miRs to target multiple genes and biological signalin...

    Authors: Molly A Taylor and William P Schiemann
    Citation: Molecular and Cellular Therapies 2014 2:30
    Content type: Review Published on:

  18. We recently synthesized a hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide-co-N-(3-azidopropyl)methacrylamide), p(HPMA-co-AzMA), by RAFT polymerization using a novel azide-containing methacrylamide mon...

    Authors: Morten F Ebbesen, Konrad Bienk, Bent W Deleuran and Kenneth A Howard
    Citation: Molecular and Cellular Therapies 2014 2:29
    Content type: Short report Published on:

  19. The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper acti...

    Authors: Artem Blagodatski, Dmitry Poteryaev and Vladimir L Katanaev
    Citation: Molecular and Cellular Therapies 2014 2:28
    Content type: Review Published on:

  21. Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder characterized by the selective degeneration of defined subgroups of motoneuron in the brainstem, spinal cord and motor cortex with sig...

    Authors: Manoj Kumar Jaiswal
    Citation: Molecular and Cellular Therapies 2014 2:26
    Content type: Review Published on:

  22. Allogeneic stem cell transplantation (alloSCT) is the most robust form of adoptive cellular therapy (ACT) and has been tremendously effective in the treatment of leukemia. It is one of the original forms of ca...

    Authors: Haven R Garber, Asma Mirza, Elizabeth A Mittendorf and Gheath Alatrash
    Citation: Molecular and Cellular Therapies 2014 2:25
    Content type: Review Published on:

  23. Despite ongoing research efforts and attempts to bring new drugs into trial, the prognosis for brain tumors remains poor. Patients with the most common and lethal intracranial neoplasia, glioblastoma multiform...

    Authors: Veronica Mariotti, Steven J Greco, Ryan D Mohan, George R Nahas and Pranela Rameshwar
    Citation: Molecular and Cellular Therapies 2014 2:24
    Content type: Review Published on:

  24. Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin – the protective shea...

    Authors: Stuart I Jenkins, Humphrey H P Yiu, Matthew J Rosseinsky and Divya M Chari
    Citation: Molecular and Cellular Therapies 2014 2:23
    Content type: Review Published on:

  25. The Wnt signaling pathway is long known to play fundamental roles in various aspects of embryonic development, but also in several homeostatic processes controlling tissue functions in adults. The complexity o...

    Authors: Timur A Yorgan and Thorsten Schinke
    Citation: Molecular and Cellular Therapies 2014 2:22
    Content type: Review Published on:

  26. Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in adults. Despite current treatment modalities, such as surgical resection followed by chemotherapy and radiotherapy, onl...

    Authors: Hidehiro Okura, Christian A Smith and James T Rutka
    Citation: Molecular and Cellular Therapies 2014 2:21
    Content type: Review Published on:

  28. Progress is being made in developing neuroprotective strategies for traumatic brain injuries; however, there will never be a therapy that will fully preserve neurons that are injured from moderate to severe he...

    Authors: Nolan B Skop, Frances Calderon, Cheul H Cho, Chirag D Gandhi and Steven W Levison
    Citation: Molecular and Cellular Therapies 2014 2:19
    Content type: Review Published on:

  29. Small non-coding microRNA RNA molecules can regulate stem cell function. The role of microRNAs in neural stem/progenitor cells (NS/PCs) differentiation is not entirely clear.

    Authors: Maged M Harraz, Jin-Chong Xu, Noah Guiberson, Ted M Dawson and Valina L Dawson
    Citation: Molecular and Cellular Therapies 2014 2:18
    Content type: Research article Published on:

  30. There has been a recent paradigm shift in the way we target cancer, drawing a greater focus on the role of the tumor microenvironment (TME) in cancer development, progression and metastasis. Within the TME, th...

    Authors: Taylor C Remillard, Gennady Bratslavsky, Sandra Jensen-Taubman, William G Stetler-Stevenson and Dimitra Bourboulia
    Citation: Molecular and Cellular Therapies 2014 2:17
    Content type: Review Published on:

  31. Chemoresistance is one of the main problems in the therapy of cancer. There are a number of different molecular mechanisms through which a cancer cell acquires resistance to a specific treatment, such as alter...

    Authors: Sara Donzelli, Federica Mori, Francesca Biagioni, Teresa Bellissimo, Claudio Pulito, Paola Muti, Sabrina Strano and Giovanni Blandino
    Citation: Molecular and Cellular Therapies 2014 2:16
    Content type: Review Published on:

  32. Membrane transporters play critical roles in moving a variety of anticancer drugs across cancer cell membrane, thereby determining chemotherapy efficacy and/or toxicity. The retention of anticancer drugs in ca...

    Authors: Qing Li and Yan Shu
    Citation: Molecular and Cellular Therapies 2014 2:15
    Content type: Review Published on:

  34. Myocardial infarctions constitute a major factor contributing to non-natural mortality world-wide. Clinical trials ofmyocardial regenerative therapy, currently pursued by cardiac surgeons, involve administrati...

    Authors: Marek Malecki, Emily Putzer, Chelsea Sabo, Afsoon Foorohar, Carol Quach, Chris Stampe, Michael Beauchaine, Xenia Tombokan, Raf Malecki and Mark Anderson
    Citation: Molecular and Cellular Therapies 2014 2:13
    Content type: Research article Published on:

  36. Although the host gene expression in the context of HIV has been explored by several studies, it remains unclear how HIV is able to manipulate and subvert host gene machinery before and after highly active ant...

    Authors: Viviane N da Conceicao, Wayne B Dyer, Kaushal Gandhi, Priyanka Gupta and Nitin K Saksena
    Citation: Molecular and Cellular Therapies 2014 2:11
    Content type: Research article Published on:

  37. Human immunodeficiency virus (HIV) is still a serious global health concern responsible for more than 25 million deaths in last three decades. More than 34 million people are living with HIV infection. Macroph...

    Authors: Amit Kumar and Georges Herbein
    Citation: Molecular and Cellular Therapies 2014 2:10
    Content type: Review Published on:

  40. MicroRNAs (miRNAs or miRs) are a family of small non-coding RNA species that have been implicated in the control of many fundamental cellular and physiological processes such as cellular differentiation, proli...

    Authors: Sacha I Rothschild
    Citation: Molecular and Cellular Therapies 2014 2:7
    Content type: Review Published on:

  41. We have reported that pH values of ascites and interstitial fluids around the liver in Otsuka Long-Evans Tokushima Fatty (OLETF) rats are significantly lower than normal pH, 7.40, of mammalian body fluids (Bio...

    Authors: Yoshinori Marunaka, Kanji Yoshimoto, Wataru Aoi, Shigekuni Hosogi and Hiroshi Ikegaya
    Citation: Molecular and Cellular Therapies 2014 2:6
    Content type: Short report Published on:

  42. Utilizing RNA interference as an innovative therapeutic strategy has an immense likelihood to generate novel concepts in precision medicine. Several clinical trials are on the way with some positive initial re...

    Authors: Dan Peer
    Citation: Molecular and Cellular Therapies 2014 2:5
    Content type: Review Published on:

  44. In the previous studies, telocytes were found near the capillaries in many tissues, especially on the extracellular matrix of blood vessels and positive to CD34 and c-kit. Therefore, the present study aimed to...

    Authors: Yonghua Zheng, Xiaoke Chen, Mengjia Qian, Miaomiao Zhang, Ding Zhang, Chunxue Bai, Qun Wang and Xiangdong Wang
    Citation: Molecular and Cellular Therapies 2014 2:3
    Content type: Research article Published on:

  45. For a range of nervous system disorders current treatment options remain limited. Focusing on Parkinson’s disease as a neurodegenerative entity that affects an increasing quantity of people in our aging societ...

    Authors: Jan Pruszak
    Citation: Molecular and Cellular Therapies 2014 2:2
    Content type: Commentary Published on:

  46. HIV eradication strategies are now being evaluated in vitro and in vivo. A cornerstone of such approaches is maximal suppression of viral replication with combination antiretroviral therapy (ART). Since many anti...

    Authors: Nathan W Cummins, Amy M Sainski, Sekar Natesampillai, Gary D Bren and Andrew D Badley
    Citation: Molecular and Cellular Therapies 2014 2:1
    Content type: Research article Published on:

  47. Expanding knowledge about the crucial roles of microRNAs (miRNAs) in human diseases has led to the idea that miRNAs may be novel, promising therapeutic targets against various pathological conditions. The rece...

    Authors: Chikako Shibata, Motoyuki Otsuka, Takahiro Kishikawa, Takeshi Yoshikawa, Motoko Ohno, Akemi Takata and Kazuhiko Koike
    Citation: Molecular and Cellular Therapies 2013 1:5
    Content type: Review Published on:

  48. Ongoing clinical trials, in regenerative therapy of patients suffering from myocardial infarctions, rely primarily upon administration of bone marrow stem cells to the infarcted zones. Unfortunately, low reten...

    Authors: Marek Malecki, Chelsea Sabo, Emily Putzer, Chris Stampe, Afsoon Foorohar, Carol Quach, Michael Beauchaine, Xenia Tombokan and Mark Anderson
    Citation: Molecular and Cellular Therapies 2013 1:4
    Content type: Research article Published on:

  50. Gene therapy is suggested to be one of the most specific and efficient modulations for gene deficient diseases and extended to other diseases like cancer and inflammation, even though there are still challenge...

    Authors: Xiangdong Wang, Dan Peer and Bryon Petersen
    Citation: Molecular and Cellular Therapies 2013 1:1
    Content type: Editorial Published on:

Molecular and Cellular Therapies

ISSN: 2052-8426

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