Figure 1

Schematic model of the transporters in major organs responsible for drug disposition. The SLC members reviewed here may play an important role in determining the pharmacokinetics of anti-cancer drugs. They may be involved in drug absorption at the intestine, drug uptake into the liver for metabolism, drug elimination in the kidney, and drug distribution in a variety of additional tissues such as heart, lung, and brain. To facilitate understanding of drug transport processes in the organs, important efflux ABC transporters, which are reviewed elsewhere, are also depicted. Influx SLC transporters are shown as yellow open ovals and efflux SLC transporters as green open ovals. Some SLC transporters which mediate bi-directional transport are depicted by blue open ovals. ABC transporters are shown in black ovals. Black solid arrows indicate the direction of drug transport.