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Fig. 2 | Molecular and Cellular Therapies

Fig. 2

From: Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling

Fig. 2

Analysis of TNF and mutein TNF07 on Western Blots under non-reduced and reduced conditions. Analysis on Western blot of TNF07 and sTNF under non-reducing conditions reveals sTNF (right lane) remains a monomer with approximate molecular weight (MW) of 25kD and the TNF07 (left lane) remains as a trimer with approximate MW of 75 kDa. With reduction, the stable TNF07 trimer becomes predominately a monomer with a 25kD MW (center lane)

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Molecular and Cellular Therapies

ISSN: 2052-8426

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