Skip to main content
Fig. 1 | Molecular and Cellular Therapies

Fig. 1

From: Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling

Fig. 1

The 3D model of the covalently cross-linked TNF07 mutein. a Top view of the S95C/G148C double mutant. The three monomers are shown in cartoon representation and the monomers are colored in blue, purple and green. The surface representation is also shown in light grey. Red rectangles highlight the three Cys-Cys double bonds between each monomer. Residues 95 and 148 are shown in ball and stick representation. b Side view of the S95C/G148C double mutant. Red rectangle highlights one of the Cys-Cys double bonds and the insert shows the close up view. The model was generated by Modeller (v.9.12) [24] using the structure of mouse TNF (PDB ID: 2TNF) as the template. The pictures were created by the program PyMOL [25]

Back to article page