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Table 2 Statistical differences in AUC between each of the test arms and the active control arm. PP110 Gel is more effective than Preparation-H® with respect to bleeding, pain and itching (in a manner that is statistically significant). PP110 Wipes are more effective than Preparation-H® with respect to swelling, but less effective with respect to pain and discomfort

From: A prospective, randomized, three arm, open label study comparing the safety and efficacy of PP110, a novel treatment for hemorrhoids to preparation-H® maximum strength cream in the treatment of grade 2–3 hemorrhoids

Symptom

PP110 Gel vs. Preparation-H®

PP110 Wipes vs. Preparation-H®

Difference

Lower CI

Upper CI

P-value

Difference

Lower CI

Upper CI

P-value

Bleeding

−0.06

−0.10

−0.02

0.0059

−0.03

−0.08

0.02

0.2034

Pain

−0.12

−0.19

−0.04

0.0025

0.15

0.05

0.25

0.0023

Itching

−0.13

−0.21

−0.05

0.0008

−0.01

−0.10

0.07

0.7673

Swelling

−0.00

−0.05

0.05

0.9367

−0.15

−0.20

−0.10

<.0001

Discharge

−0.01

−0.06

0.04

0.6908

0.05

−0.02

0.12

0.1344

Discomfort

0.06

−0.01

0.14

0.0958

0.10

0.03

0.18

0.0084