Candidate name | Disease | Target | Delivery system | Phase | Year |
---|---|---|---|---|---|
Bevasiranib | AMD | VEGF | Local - intravitreal needle injection. | lll - was interupted in 2009 | 2004 |
Cand5 | AMD, DME | VEGF | Local - intravitreal needle injection. | ll | 2004 |
ALN-RSV01 | RSV infection | Virial RNA | Local - inhalation of unformulated siRNAs. | ll | 2005 |
DGFi | Acute kidney injury, delayed graft function | p53 | Systematic - naked siRNA | ll | 2007 |
TD101 | Pachyonychia congenita | Mutant keratin (K6a) | Local - intradermal needle injection | l | 2008 |
QPI-2007 | Chronic nerve atrophy, nonarteritic ischemic optic neurophaty | Caspace 2 | Local - intravitreal needle injection | l | 2009 |
siG12D LODER | Operable pancreatic ductal adenocarcinoma | Mutated KRAS | Local - drug elution | l | 2010 |
CALAA-01 | Metastatic solid tumors | RRM2 | Systematic - CDP NPs | l | 2008 |
ALN-VSP02 | Liver cancer, cancer with liver involvement | VEGF, KSP | Systematic - SNALP liposomes (hypatocytes) | l | 2008 |
Atu027 | Advanced solid tumors | PKN3 | Systematic - AtuPLEX lipoplex (vascular endothelial cells) | l | 2009 |
TKM-ApoB | Hypercolesterolemia | ApoB | Systematic - SNALP liposomes (hypatocytes) | l | 2009 |
ALN-TTR01 | ATTR | TTR | Systematic - SNALP liposomes (hypatocytes) | l | 2009 |
TKM-PLK1 | Solids cancers and lymphoma | PLK1 | Systematic - SNALP liposomes (solid tumors) | l | 2010 |
ALN-PCS02 | Hypercolesterolemia | PCSK9 | Systematic - SNALP liposomes (solid tumors) | l | 2011 |
TKM-EBOLA | Ebola infection (biodefence) | Viral RNA polymerase | Systemic - SNALP liposomes (hypotocytes and phagocytes) | l | 2011 |