Figure 3

Dye-labeled p(HPMA- co -AzMA) joint accumulation profiles. 62% of the 54 kDa dye-labeled copolymer (Pol-dye) was retained in arthritic joints of DBA/1 mice at 24 h. Polymer bioavailability (AUC) was 1783 and 148% · h in arthritic (n = 16 joints, 4 mice) and healthy (n = 16 joints, 4 mice) joints. Dye alone was included as control with AUC of 4.48 and 8.96% · h in arthritic (n = 4 joints, 1 mouse) and healthy (n = 8 joints, 2 mice). Joint polymer levels are normalized to the highest mean value and averages shown with SEM.