Figure 2

Blood circulation profiles. Blood circulation profiles of dye-labeled p(HPMA- co -AzMA) of 15, 36 and 54 kDa (PBS as control) in BALB/c mice. Polymer levels were normalized to the value measured at 5 min. 10% of the 54 kDa polymer was retained in the blood at 24 h Polymer bioavailability (AUC) are 698, 313 and 45% · h for polymers of 54, 36 and 15 kDa, respectively. Polymer circulation half-life was calculated to 6.4, 2.8 and < 0.33 h for polymers of 54, 36 and 15 kDa, respectively. Averages of n = 3 mice are shown with SEM.