Figure 2

Diagram of ACT within the alloSCT platform. T-cell depleted SCT would eliminate the need for post-SCT immunosuppressive medications that can limit the efficacy of modified T-cells. Since allogeneic cells are used, the endogenous specificity of the T-cells would be pre-selected (CMV, EBV, varicella, etc.) or other GvHD prevention measures would need to be incorporated, such as naïve T cell depletion.