Stem cell in alternative treatments for brain tumors: potential for gene delivery

Table 3 Cancer targeting agents delivered by stem cells for glioblastoma

Drug/gene	Stem cell	Targeting method	References
Cytosine deaminase (CD)	NSCs	Indirect via conversion of prodrug, 5-fluorocytosine (5-FC)	[36]
CD	MSCs	Indirect, via conversion of the prodrug. 5-FC	[27]
MSN-dox	NSCs	Direct	[55]
Soluble TRAIL	MSCs	Direct	[56]
miR-9	MSCs	Direct	[2]
Fc-diOH-LNC	MIAMIs	Direct	[28]

Shown are representatives methods by which drug/gene/RNA can be used in stem cell delivery system for the treatment of glioblastoma. Direct method indicates that the stem cells release the drug, which interacts with the cancer cells for cytotoxic effects. Indirect effects are indicated when an enzyme is delivered in the stem cells for the local conversion of a prodrug to its active form.

ISSN: 2052-8426