Figure 3

Strategy of cytokine mediated gene therapy. Cytokine mediated gene therapy involves tumor-selective gene transfer and in situ expression of various cytokine genes such as interleukin (IL) and interferon (IFN) capable of attracting immunocompetent cells such as macrophages (MΦ), natural killer cells (NK), and cytotoxic T lymphocytes (CTL) inducing immune response.