Table 1 Matrix metalloproteinases (MMPs) categories
From: Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment
Secreted MMPs | Â | Membrane bound MMPs | ||
|---|---|---|---|---|
| Â | Â | Type I transmembrane | GPI- anchored | Type II transmembrane |
MMP-1 | MMP-2 | MMP-14 | MMP-17 | MMP-23A |
MMP-3 | MMP-7 | MMP-15 | MMP-25 | MMP-23B |
MMP-8 | MMP-9 | MMP-16 | Â | Â |
MMP-10 | MMP-11 | MMP-24 | Â | Â |
MMP-12 | MMP-13 | Â | Â | Â |
MMP-19 | MMP-20 | Â | Â | Â |
MMP-21 | MMP-27 | Â | Â | Â |
MMP-28 | Â | Â | Â | Â |
Structure and substrate specificity | ||||
Collagenases | Gelatinases | Stromelysins | Matrilysins | Membrane-Type |
MMP-1 | MMP-2 | MMP-3 | MMP-7 | MMP-14 |
MMP-8 | MMP-9 | MMP-10 | MMP-26 | MMP-15 |
MMP-13 | Â | MMP-11 | Â | MMP-17 |
MMP-18 | Â | Â | Â | MMP-24 |
| Â | Â | Â | Â | MMP-25 |