Skip to main content
Figure 9 | Molecular and Cellular Therapies

Figure 9

From: Directed cardiomyogenesis of autologous human induced pluripotent stem cells recruited to infarcted myocardium with bioengineered antibodies

Figure 9

Functional tests of contractile apparatus and adrenergic receptors in developing cardiomyocytes. A. Differentiation of cardiomyocytes was determined by qRTPCR of the transcripts for adrenergic β1 (AdrR) receptors normalized by ratios with GAPDH over time. The PBMCs served as the controls. B. Functional maturity of the AdrRs was quantified by measuring the beat rate in embryoid bodies after treatment with increasing concentrations of Isoprenaline - adrenergic β1 agonist. C. Expression of adrenergic β1 (AdrR) receptors in the differentiating hESCs (lane 4) and ahiPSCs (lane 3) was compared to the cardiac tissue (lane 2) and standard (lane 1), while the undifferentiated ahiPSCs (lane 5) and the PBMCs served as the controls (lane 6).

Back to article page

Molecular and Cellular Therapies

ISSN: 2052-8426

Contact us