Figure 1

Concept for recruitment of human pluripotent stem cells to sarcomeres of infarcted myocardium. Sarcomeric proteins include: myosin (in A-band), α-actinin (in Z-line), actin (I-band), titin (with various domains stretched between Z-lines). Autologous human induced pluripotent stem cells (ahiPSCs) display on their surfaces biomarkers: SSEA-4, TRA-1-60, SSEA-3, TRA-1-81. Heterospecific tetravalent antibodies (htAbs) target the sarcomeric proteins and simultaneously the pluripotent stem cells’ biomarkers. Four phases of recruitment are shown: (A – injection of htAbs, B – anchoring to sarcomeres; C – injection of ahiPSCs; D – anchoring of ahiPSCs). For clarity of the presentation, only bonds between myosin, α-actinin and TRA-1-60, SSEA-4 are shown.