Table 4 Over representation of genes significant in TP1 versus TP2 comparison, based on the top 5 significant pathways

IFI6

p < = 0.001198

Regulation of apoptosis

Down

IFN- β*

p < = 0.001647

Antiviral activity which is Mainly involved in innate immune response

Down

IFN-γ*

p < = 0.008242

Critical for innate and adaptive immunity against Viral and intracellular bacterial infections and for tumor control

Down

IL-1β*

p < = 0.005439

An important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis

Down

IL-6*

p < = 0.002616

Acts as both a pro-inflammatory and anti-inflammatory cytokine; stimulate immune response

Down

IL1RN

p < = 0.0007325

Inhibits the activity of IL-1 by binding to its receptor

Down

ISG15

p < = 0.0007325

Antiviral activity during viral infections

Down

ISG54

p < = 0.0004398

Restrict virus infection through alteration of cellular protein synthesis

Down

MIP-α

p < = 0.0003696

Involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes

Down

OAS1*

p < = 0.002616

Involved in the innate Immune response to viral infection

Up

OAS2*

p < = 0.004717

Involved in the innate Immune response to viral infection

Up

OAS3*

p < = 2.622e-05

Involved in the innate Immune response to viral infection

Up

PKR*

p < = 0.01396

Inhibits further cellular mRNA translation, thereby preventing viral Protein synthesis; induce cellular apoptosis, to prevent further viral spread

Down

STAT1

p < = 0.002616

Signal transducer and activator of transcription that mediates signaling by interferons

Up

STAT2

p < = 0.01797

Signal transducer and activator of transcription that mediates signaling by type I IFNs

Up

WARS

p < = 0.006259

Catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon; associated with angiogenesis

Up